The purposes of this research were to study the quality of sleep and its related variables and predictors as perceived by professional nurses. The methods of random sampling was used to select 160 professional nurses, who were questioned about their family responsibility, sleep hygiene, stress of practice, sleep environment and quality of sleep (scale 0-21). The question content validity was checked by three experts and each area had a Cronbach's alpha reliability of 0.79, 0.70, 0.94, 0.94 and 0.70, respectively. Statistical analysis by percentage, mean, standard deviation, Pearson's product moment  correlation coefficient, and stepwise multiple regression analysis were used for data analysis and representation. The results findings were the quality of sleep of professional nurses was “bad” (x = 8.03, SD = 2.33), by have health status, sleep hygiene, days of morning shift, sleep environment and age (r = 0.372, 0.336, 0.305, 0.295 and 0.212, respectively), while stress of practice had a negative relationship (r = -0.309), for variables that significantly predicted the quality of sleep at p < 0.05 were health status, days of morning shift, sleep environment and sleep hygiene, which accounted for 29.1% of the variance. In conclusion, the positive selected factors relating to the sleep quality of nurses are health status, days of morning shift, sleep environment, sleep hygiene and age. The effect of study are guideline set schedule and to concern about sleep environment, health status, sleep hygiene, and the sleep effect to quality of sleep.